Washington, Sep 25 (ANI): Researchers can now tell what number a person has just seen or how many dots he or she has been presented with, by a careful observation and analysis of the brain activity pattern.

This research work confirms the notion that numbers are encoded in the brain via detailed and specific activity patterns, and opens the door to more sophisticated exploration of humans' high-level numerical abilities.

Although "number-tuned" neurons have been found in monkeys, scientists have not yet gone beyond particular brain regions in humans.

"It was not at all guaranteed that with functional imaging it would be possible to pick this upIn the monkey, neurons preferring one or the other numerosity appear highly intermixed among themselves as well as with neurons responding to other things, so it might seem highly unlikely that with fMRI [functional magnetic resonance imaging] at 1.5 mm resolution-where one voxel contains many thousands of neurons-one would be able to detect differences in activity patterns between individual numbers," said Evelyn Eger of INSERM in France.

"The fact that this worked means that there is probably a somewhat more structured layout of preferences for individual numbers that has yet to be revealed by neurophysiological methods," she added.

In the study, the researchers presented ten participants with either number symbols or dots while their brains were scanned with fMRI.

They then used a multivariate analysis method to devise a way of decoding the numbers or number of dots people had observed.

It was found that although the brain patterns corresponding to number symbols differed somewhat from those for the same number of objects, the numerosity of dot sets can be predicted above chance from the brain activation patterns evoked by digits, the researchers show.

However, it does not work the other way around.

At least for small numbers of dots, the researchers did find that the patterns change gradually in a way that reflects the ordered nature of the numbers-allowing one to conclude that 6 is between 5 and 7, for instance.

In the case of digits, the researchers could not detect that same gradual change, suggesting that their methods are not yet sensitive enough or that digits are in fact coded as more precise, discrete entities.

The methods used in the new study may ultimately help to unlock how the brain makes more sophisticated calculations, the researchers say.

"With these codes, we are only beginning to access the most basic building blocks that symbolic math probably relies on. We still have no clear idea of how these number representations interact and are combined in mathematical operations, but the fact that we can resolve them in humans gives hope that at some point we can come up with paradigms that let us address this," said Eger.

The study has been published online in Current Biology, a Cell Press publication. (ANI)